One of Virginia’s most revered Founding Fathers, George Wythe, exhaled his last breath on June 8, 1806, at his home at 5th and Grace Streets, dead of rat poisoning. He has the dubious distinction of being the only signer of the Declaration of Independence to be murdered. Arsenic was the method, distributed in the morning breakfast by the hand of a deranged great-nephew, looking for an early inheritance.