David and Paige Walling and Terry and Cathy Ostroff are best friends and neighbors living on Orange Drive in suburban New Jersey. Their comfortable existence goes awry when prodigal daughter Nina Ostroff, newly broken up with her fiancé Ethan, returns home for Thanksgiving after a five-year absence. Rather than developing an interest in the successful son of her neighbors, Toby Walling, which would please both families, it's her parents' best friend David who captures Nina's attention.
When the connection between Nina and David becomes undeniable, everyone's lives are thrown into upheaval. It's not long before the ramifications of the affair begin to work on all of the family members in unexpected and hilarious ways.